Elemental speciation analysis/metallomics
The group addresses analytical method development in the field of elemental speciation analysis. From the definition of elemental speciation analysis (see IUPAC Guidelines for Terms Related to Speciation of Trace Elements, Pure Appl. Chem., 72/8 (2000) 1453-1470.) it can be inferred that within this discipline all molecules containing metals, metalloids, sulfur, and phosphorus are perceived and accordingly analyzed as chemical species of these respective elements. Of course, this encompasses the technologies of chromatography, atomic spectroscopy, complementary elemental and molecular mass spectrometry and the understanding of the fundamentals that underscore their analytical characteristics. It includes the statistics of analytical determination and validation of same.
Metallomics was introduced in 2004, with reference to the multidisciplinary “omics” fields, emphasizing the awareness that the “omic” revolution brought to atomic spectroscopy and to analytical chemistry in general. Importantly, metallomics includes speciation in its most general form, including the study of how the elements are complexed and the environmental and human health impact of that complexation.
Applications
- Elemental speciation analysis in preclinical cancer research
Cooperation with Institute of Cancer Research, Department of Medicine I, Medical University of Vienna; Institute of Inorganic Chemistry, University of Vienna; Metallomics Platform Vienna, Department of Chemistry, University of Natural Resources and Life Sciences - Metallomics: Metrology for Metalloproteins (http://www.ptb.de/emrp/739.html) European Metrology Research programme
Metabolomics
Quantitative metabolomics is under intense development, and no commonly accepted standard analytical technique has emerged, yet. The chemical diversity of the metabolome calls for multidimensional analysis using different measurement platforms in order to fulfil the requirements of the global “omics” approaches. Major objective of the group is the development and thorough validation of methods based on multidimensional liquid chromatography in combination with mass spectrometry aiming at high coverage of the metabolic network. Targeted quantitative methods by tandem mass spectrometry and untargeted metabolomics fingerprinting approaches using high mass accuracy instrumentation are addressed.
Applications
Metabolomics in biotechnology
Cooperation with Department of Biotechnology, Department of Chemistry, University of Natural Resources and Life Sciences, Austrian Centre of Industrial Biotechnology (ACIB, http://www.acib.at), project cellular analysis within EQ-VIBT (http://eq-vibt.boku.ac.at/)
University of Vienna
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1010 Vienna
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